The research developed in the Nutrigenomics, Bioactives and Health lab aims to demonstrate health effects of micronutrients, particularly polyphenols, on (neuro)vascular function and development and/or prevention of cardiovascular, metabolic and neurodegenerative diseases using a translational approach involving in-vitro studies, animal models and clinical trials. The lab also aims to decipher complex cellular and molecular mechanisms of action underlying the health properties of bioactives using integrated multigenomics and bioinformatics that includes transcriptomics of different types of RNAs (mRNAs, miRNAs, lncRNAs, snoRNAs, circRNAs) using microarrays, RNAseq, single-cell RNAseq and spatial transcriptomics; proteomics; in-silico 3D binding molecular modeling. Such studies also allow us to identify variability in responsiveness to intake of these bioactives and bioactive-rich foods and identify factors involved (gender, age, health status or genetic polymorphism) for application in precise nutrition.